Shifting the limits in wheat research and breeding using a fully annotated reference genome
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- R. Appels, Kellye Eversole, Nils Stein, Catherine Feuillet, Beat Keller, Jane Rogers, Curtis Pozniak, Frédéric Choulet, Assaf Distelfeld, Jesse Poland, Gil Ronen, Andrew Sharpe, Omer Barad, Kobi Baruch, Gabriel Keeble‐Gagnère, Martin Mascher, Gil Ben-Zvi, Ambre-Aurore Josselin, Axel Himmelbach, François Balfourier, Juan J. Gutiérrez-González, Matthew Hayden, ChuShin Koh, Gary J. Muehlbauer, Raj Pasam, Etienne Paux, Philippe Rigault, Josquin Tibbits, Vijay Tiwari, M. Spannagl, Daniel Lang, Heidrun Gundlach, Georg Haberer, Klaus Mayer, Danara Ormanbekova, Verena M. Prade, Hana Šimková, Thomas Wicker, David Swarbreck, Hélène Rimbert, Marius Felder, Nicolas Guilhot, Gemy Kaithakottil, Jens Keilwagen, Philippe Leroy, Thomas Lux, Sven Twardziok, Luca Venturini, Angéla Juhász, Michaël Abrouk, Iris Fischer, Cristóbal Uauy, Philippa Borrill, Ricardo H. Ramírez-González, Dominique Arnaud, Smahane Chalabi, Boulos Chalhoub, Aron T. Cory, Raju Datla, Mark W. Davey, John Jacobs, Stephen J. Robinson, Burkhard Steuernagel, Fred van Ex, Brande B. H. Wulff, Moussa Benhamed, Abdelhafid Bendahmane, Lorenzo Concia, David Latrasse, Jan Bartoš, Arnaud Bellec, Hélène Bergès, Jaroslav Doležel, Zeev Frenkel, Bikram Gill, Abraham B. Korol, Thomas Letellier, Odd-Arne Olsen, Kuldeep Singh, Miroslav Valárik, Edwin van der Vossen, Sonia Vautrin, Song Weining, Tzion Fahima, Vladimir Glikson, Dina Raats, Jarmila Číhalíková, Helena Toegelová, Jan Vrána, Pierre Sourdille, Benoît Darrier, Delfina Barabaschi, Luigi Cattivelli, Pilar Hernández, Sergio Gálvez, Hikmet Budak, Jonathan D. G. Jones, Kamil Witek, Guotai Yu, Ian Small
- Journal
- Science
- Year
- 2018
- Citations
- 3,353
Abstract
An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue- and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development. Dynamics of complex gene families involved in environmental adaptation and end-use quality were revealed at subgenome resolution and contextualized to known agronomic single-gene or quantitative trait loci. This community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.